Oladimeji, S. O. and Babafemi, S. A. and Igbalaye, J. O. and Oyedola, J. O. and Olusanya, A. R. and Bolarinwa, A. R. (2022) Methanolic Extract of Tapinanthus bangwensis Exhibits Pro-Fertility and Antioxidant Activities in Female Albino Rats. South Asian Research Journal of Natural Products, 5 (3). pp. 42-51.
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Abstract
Aims: To determine the effect of methanolic extract of Tapinanthus bangwensis on reproductive hormones and antioxidant enzymes in female Wistar rats.
Study Design: Experimental Research.
Place and Duration of Study: Department of Biochemistry, Lagos State University, Lagos Nigeria between November 2019 and February 2020.
Methodology: A total of 40 rats were used and were divided into eight groups of 5 rats. The study was carried out for 21 days, the rats were induced with Postinor-2 for 7 days after which Tapinanthus bangwensis extract was administered for 14 days and was compared against the vehicle (oil), Postinor-2, and extract controls. Hormonal level estimation (Progesterone and prolactin) and in-vivo antioxidant enzyme activity (catalase, superoxide dismutase (SOD), and alkaline phosphatase activity) were estimated using standard procedures.
Results: The extract administration showed a significant increase (p<0.01, p<0.05) in the level of prolactin concentration in the PLD group (2.027ng/ml) compared to other groups. Also, there was an increased (p<0.01) progesterone concentration in the ILD group (65.35ng/ml) as compared to other groups (CIC). The extract-only (EO) group had the highest level of catalase activity (2.331U/ml), compared with all extract groups and there was no significance in the SOD level across the different groups. Lastly, there was a significant increase in the activity of alkaline phosphatase in the EO and ILD groups (p<0.05) compared to the COO group.
Conclusion: The methanolic extract of Tapinanthus bangwensis exhibits pro-fertility and antioxidant activities.
Item Type: | Article |
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Subjects: | STM Library > Chemical Science |
Depositing User: | Managing Editor |
Date Deposited: | 19 Dec 2022 07:43 |
Last Modified: | 16 Mar 2024 04:41 |
URI: | http://open.journal4submit.com/id/eprint/944 |