Methanolic Extract of Tapinanthus bangwensis Exhibits Pro-Fertility and Antioxidant Activities in Female Albino Rats

Oladimeji, S. O. and Babafemi, S. A. and Igbalaye, J. O. and Oyedola, J. O. and Olusanya, A. R. and Bolarinwa, A. R. (2022) Methanolic Extract of Tapinanthus bangwensis Exhibits Pro-Fertility and Antioxidant Activities in Female Albino Rats. South Asian Research Journal of Natural Products, 5 (3). pp. 42-51.

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Abstract

Aims: To determine the effect of methanolic extract of Tapinanthus bangwensis on reproductive hormones and antioxidant enzymes in female Wistar rats.

Study Design: Experimental Research.

Place and Duration of Study: Department of Biochemistry, Lagos State University, Lagos Nigeria between November 2019 and February 2020.

Methodology: A total of 40 rats were used and were divided into eight groups of 5 rats. The study was carried out for 21 days, the rats were induced with Postinor-2 for 7 days after which Tapinanthus bangwensis extract was administered for 14 days and was compared against the vehicle (oil), Postinor-2, and extract controls. Hormonal level estimation (Progesterone and prolactin) and in-vivo antioxidant enzyme activity (catalase, superoxide dismutase (SOD), and alkaline phosphatase activity) were estimated using standard procedures.

Results: The extract administration showed a significant increase (p<0.01, p<0.05) in the level of prolactin concentration in the PLD group (2.027ng/ml) compared to other groups. Also, there was an increased (p<0.01) progesterone concentration in the ILD group (65.35ng/ml) as compared to other groups (CIC). The extract-only (EO) group had the highest level of catalase activity (2.331U/ml), compared with all extract groups and there was no significance in the SOD level across the different groups. Lastly, there was a significant increase in the activity of alkaline phosphatase in the EO and ILD groups (p<0.05) compared to the COO group.

Conclusion: The methanolic extract of Tapinanthus bangwensis exhibits pro-fertility and antioxidant activities.

Item Type: Article
Subjects: STM Library > Chemical Science
Depositing User: Managing Editor
Date Deposited: 19 Dec 2022 07:43
Last Modified: 16 Mar 2024 04:41
URI: http://open.journal4submit.com/id/eprint/944

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