Toney, Ashley Mulcahy and Fox, Darius and Chaidez, Virginia and Ramer-Tait, Amanda E. and Chung, Soonkyu (2021) Immunomodulatory Role of Urolithin A on Metabolic Diseases. Biomedicines, 9 (2). p. 192. ISSN 2227-9059
biomedicines-09-00192-v2.pdf - Published Version
Download (777kB)
Abstract
Urolithin A (UroA) is a gut metabolite produced from ellagic acid-containing foods such as pomegranates, berries, and walnuts. UroA is of growing interest due to its therapeutic potential for various metabolic diseases based on immunomodulatory properties. Recent advances in UroA research suggest that UroA administration attenuates inflammation in various tissues, including the brain, adipose, heart, and liver tissues, leading to the potential delay or prevention of the onset of Alzheimer’s disease, type 2 diabetes mellitus, and non-alcoholic fatty liver disease. In this review, we focus on recent updates of the anti-inflammatory function of UroA and summarize the potential mechanisms by which UroA may help attenuate the onset of diseases in a tissue-specific manner. Therefore, this review aims to shed new insights into UroA as a potent anti-inflammatory molecule to prevent immunometabolic diseases, either by dietary intervention with ellagic acid-rich food or by UroA administration as a new pharmaceutical drug.
Item Type: | Article |
---|---|
Subjects: | STM Library > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 04 Mar 2023 07:06 |
Last Modified: | 04 Jun 2024 10:50 |
URI: | http://open.journal4submit.com/id/eprint/816 |