Study on the Effect of Salvia miltiorrhiza on Lowering Blood Lipid Based on Zebrafish Hyperlipidemia Model

Objective: This study investigated the lipid-lowering effects of Salvia miltiorrhiza by constructing the high blood lipid zebrafish model.

Methods: The hyperlipidemia model was constructed using egg yolk to feed the zebrafish larval. On this basis, Zebrafish larval with hyperlipidemia were treated with different concentrations of Salvia miltiorrhiza extract. Then the light density, length, cholesterol, and triglyceride content were determined. By comparing the above data between the drug treatment group and the blank group, the hypolipidemic efficacy of Salvia miltiorrhiza was analyzed.

Results: The triglyceride (TG) and total cholesterol (TC) contents of the model groups were significantly increased comparing control group, showing that the hyperlipidemia model had been effectively established. After treatment with 0.516 μg/ml, 1.135 μg/ml, and 2.325 μg/ml of Salvia miltiorrhiza extract, the lipid reduction in the hyperlipidemia model was 27.11%, 41.58%, and 62.83%, respectively. Furthermore, the TG content was reduced by 32.07%, 53.12%, and 51.46%. The TC content was reduced by 20.29%, 29.55%, and 38.80%, respectively.The data of each group were statistically significant (P<0.01).

Conclusion: Salvia miltiorrhiza has a good hypolipidemic effect in the zebrafish hyperlipidemia model. The above data provide a basis for the further development of Salvia miltiorrhiza in the field of hypolipidemic.