Kawasaki Disease can Improve Autism: A Case Report and Literature Review

In this paper, we report a case of autism in a child who was cured of Kawasaki disease and the condition of autism was significantly improved. Kawasaki disease (KD), also known as cutaneous mucosal lymph node syndrome, was first reported by Japanese doctor Tomaku Kawasaki in 1967. In recent years, domestic and foreign studies believe that the pathogenesis of KD is significantly related to infection, genetic susceptibility and immune response, and its pathogenesis and treatment still need to be further studied. The occurrence of autism may be based on genetic predisposition and triggered by environmental factors during the critical period of immune establishment at the age of 1-3 years, which causes immune-mediated inflammation, changes the permeability of gastrointestinal tract and blood-brain barrier, and leads to chronic inflammation in the central nervous system, thereby affecting neurogenesis, migration and synaptic construction.