One-Pot Green Synthesis of 1, 4-Dihydropyridine Derivatives Using Polyindole TiO2 Nanocatalyst by Solvent Free Method

Phasage, Deepak Babasaheb and Sharma, Sanjay K. and Tripathi, Balram and Srivastava, Sonia Chahar (2024) One-Pot Green Synthesis of 1, 4-Dihydropyridine Derivatives Using Polyindole TiO2 Nanocatalyst by Solvent Free Method. Open Journal of Composite Materials, 14 (03). pp. 109-123. ISSN 2164-5612

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Abstract

This study used a Polyindole in combination with TiO2 nanocatalyst as an efficient heterogeneous catalyst to carry out a multi-component Hantzsch reaction involving different aromatic aldehydes with methyl acetoacetate, and aqueous ammonium to create 1,4-dihydropyridine derivatives under solvent free condition at ambient temperature. A broad range of aldehydes and methyl acetoacetates, ranging from heteroaromatic to polyaromatic one, with high level of functional group tolerance can be used to provide the desired products possessing relevant medicinal moiety in high yields. This technology has prospective advantages over current protocols, including the utilization of a cheap, stable, recyclable, and safe catalyst, quicker reaction times with higher yields and simple product isolation.

Item Type: Article
Subjects: STM Library > Materials Science
Depositing User: Managing Editor
Date Deposited: 18 Jun 2024 11:44
Last Modified: 18 Jun 2024 11:44
URI: http://open.journal4submit.com/id/eprint/3928

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