Comorbid Cases of Immune Thrombocytopenia and Crohn’s Disease

Background and Aim: Immune thrombocytopenia (ITP) does not commonly coexist with Crohn’s disease (CD). Therefore, this review aimed to investigate studies involving patients with comorbid ITP and CD.

Methods: A literature search and review was conducted for the patients with comorbid ITP and CD, excluding those with drug or vaccination-induced ITP.

Results and Conclusion: Among 26 cases included in this review, ITP, CD, and comorbid ITP and CD were initially diagnosed in 8, 10, and 8 cases, respectively. The onset of ITP might be associated with CD aggravation in some cases. Although standard therapies in comorbid ITP and CD cases were glucocorticoids, intravenous immunoglobulin, biologics, and splenectomy, bowel resection for CD might achieve ITP remission in some cases. No fatalities were reported among 26 cases.