Toxicological Effects of Antituberculosic Chemotherapy in Adults: An Integrative Literature Review

Aguiar, Viviane Ferraz Ferreira de and Carvalho, Dayara de Nazaré Rosa de and Bendelaque, Dandara de Fátima Ribeiro and Neves, Lorena Nayara Alves and Sobrinho, Celice Ruanda Oliveira and Rocha, Paula Sousa da Silva and Costa, Rafael Everton Assunção Ribeiro da and Nascimento, Cidianna Emanuelly Melo do and Souza, Susi dos Santos Barreto de and Dergan, Marcela Raissa Asevedo and Brito, Mioni Thieli Figueiredo Magalhães and Quaresma, Juarez Antônio Simões (2021) Toxicological Effects of Antituberculosic Chemotherapy in Adults: An Integrative Literature Review. Journal of Pharmaceutical Research International, 33 (21A). pp. 50-65. ISSN 2456-9119

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Official URL: https://doi.org/10.9734/jpri/2021/v33i21A31368

Abstract

Objective: To analyze the toxicological effects of anti-tuberculosis chemotherapy in adults in national and international literature in the period from 2015 to 2020.

Methodology: It is a qualitative descriptive research, of the type Integrative Literature Review (ILR). In the VHL databases PubMed / Medline, Arca, Web of Science, Microsoft Academic and Cochrane Library. Data analysis was performed with the aid of the IRaMuTeQ software.

Results: 36 articles were found in which the following categories were created: 1) Association of hepatotoxicity and appearance of liver damage; 2) The incidence of adverse events related to antituberculin therapy; 3) Risk factors of regular consumption of antituberculins; 4) Intensive renal treatment for patients with nephrotoxicity.

Conclusion: in our review we identified that the elderly, HIV positive and alcohol users are more likely to have toxicological effects during treatment, which can lead to a possible abandonment of treatment.

Item Type:	Article
Subjects:	STM Library > Medical Science
Depositing User:	Managing Editor
Date Deposited:	23 Nov 2022 09:23
Last Modified:	27 Dec 2023 06:54
URI:	http://open.journal4submit.com/id/eprint/337

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