MACROMOLECULAR INTERACTIONS: TRENDS AND TARGETS

The morphological arrangement of interacting chemical groups in a binding or an active site presents an increased magnitude of interaction specificity and affinity which are crucial to biological functionality. The morphological configuration and functionality of macromolecules are influenced by covalent bonds and polarity, bond rotations and vibrations, non-covalent interactions, hydrophobic impact and molecular structure dynamics. Macromolecular interactions comprise diverse non-covalent interactions with specificity and precision which are crucial to biological function. Certain macromolecules are involved in the catalysis of chemical reactions or facilitate processes, such as molecular transport in ambient situations. Thus, molecular interactions are the crux of all cellular processes, viz: catalysis, recognition and signal transduction, whereby several diseases or disorders can be directly associated with aberrant interactions between molecular pairs which provide the latitude for drug designs which are capable of reversing aberrant biophysical features. Certain physical methods, such as sedimentation rate is used to investigate macromolecular interactions as a sophisticated technique that necessitates utmost precision in both the experimental design and data analysis. Kinetic analysis of an expansive array of macromolecular interactions with the evolution of experimental design and data analysis procedures make adequate provision for accurate definition of the assembly mechanisms and rate constants connected with macromolecular interactions.