Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer

Schweer, David and McCorkle, J. Robert and Rohr, Jurgen and Tsodikov, Oleg V. and Ueland, Frederick and Kolesar, Jill (2021) Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer. Biomedicines, 9 (1). p. 70. ISSN 2227-9059

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Abstract

Ovarian cancer is a highly deadly malignancy in which recurrence is considered incurable. Resistance to platinum-based chemotherapy bodes a particularly abysmal prognosis, underscoring the need for novel therapeutic agents and strategies. The use of mithramycin, an antineoplastic antibiotic, has been previously limited by its narrow therapeutic window. Recent advances in semisynthetic methods have led to mithramycin analogs with improved pharmacological profiles. Mithramycin inhibits the activity of the transcription factor Sp1, which is closely linked with ovarian tumorigenesis and platinum-resistance. This article summarizes recent clinical developments related to mithramycin and postulates a role for the use of mithramycin, or its analog, in the treatment of platinum-resistant ovarian cancer.

Item Type: Article
Subjects: STM Library > Biological Science
Depositing User: Managing Editor
Date Deposited: 08 Mar 2023 08:01
Last Modified: 14 Mar 2024 04:24
URI: http://open.journal4submit.com/id/eprint/317

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