Study of Controlled Release of Ibuprofen Using Mg Al LDH Nano Carrier

In the present study, NSAID (non-steroidal anti-inflammatory drugs) such as ibuprofen in anionic form was intercalated in-situ into the interlayer space of Mg Al LDH nanoparticles during co-precipitation of hydroxides. The structure of LDHs is comprised of positive charge compensating and exchangeable anion and water molecule. LDH nanohybrids were characterized using XRD, FTIR and UV spectroscopy. Mg1-xAlx(NO3)x(OH)2.nH2O nanoparticles were synthesized using co-precipitation method from an aqueous solution of Mg(NO3)2.6H2O and Al(NO3)3.9H2O. Ibuprofen was intercalated in inter layer space of Mg-Al LDH during coprecipitation of drug LDH conjugate in nitrogen atmosphere. The synthesized nanopowders were in the size range between 25 to 90 nm with an average particle size of 55 nm. XRD analysis proved that there was an increase in d003 spacing from 7.89 Å for pristine LDH to 14.71 Å for ibuprofen intercalated LDH due to the intercalation of bigger ibuprofen molecule in the interlayer space of LDH. FTIR analysis showed hydroxyl and carbonyl stretching of ibuprofen in LDH-IBU sample confirming the intercalation of ibuprofen in the interlayer structure of LDH. Study on drug release kinetic in phosphate buffer solution at pH 7.4 using UV-Vis spectroscopy demonstrated that 50 % drug molecules were released within 15 hours and more than 85 % release was achieved after 36 hours of incubation.