A Study on Plasmacytoma

Plasmacytoma a neoplastic proliferation of plasma cells is one of the forms of plasma cell dyscrasia that may manifest as multiple myeloma, primary amyloidosis, or monoclonal gammopathy of unknown significance. Factors such as viral pathogenesis and irritation from inhaled irritants have been noted. Genetic factors may also play a role; however, no specific loci for the origin of this disease have been identified. Plasmacytoma mainly affects people in the 5th to 6th decade of their lives. Diagnostic criteria for SP (published by the International Myeloma Working Group, IMWG) indicate that the lesion must be solitary in nature without clinical, radiographical or biochemical evidence of systemic MM. Recent guidelines recommend MRI or PET/CT evaluation, in addition to standard x-ray skeletal survey, to exclude multifocal disease [1].