Evaluation of Clinical and Magnetic Resonance in the Treatment of Knee Osteoarthritis Using Platelets and Stem Cells

The goal of this chapter is to assess the effectiveness of platelet-rich plasma therapy in conjunction with mesenchymal stem cells derived from autologous adipose tissue for the treatment of knee osteoarthritis based on clinical symptom and magnetic resonance imaging data. Osteoarthritis of the knee is a degenerative disease which can be classified into primary and secondary knee osteoarthritis. Primary knee osteoarthritis is a disease of unknown cause which is mainly related to the aging process. Secondary knee osteoarthritis with identifiable etiology includes endocrine disorders, anatomical abnormalities, post-traumatic arthritis, and septic arthritis. 30 patients including 26 females and 4 males; correspondingly, 60 knee joints were diagnosed with osteoarthritis with stages II - III of Kellgren and Lawrence, their mean age (year) were 58,63 ± 11.11. All were injected with autologous platelet-rich plasma that was extracted by PRP set, APC 30 PRP PRCEDURE PRAK and autologously extracted mesenchymal stem cells from abdominal adipose tissue using the ADI-25-01 ADIPOSEPRCEDURE PRAK of USA. After 12 months, the pain level according to VAS score at the right knee joint was decreased from 6.0 ± 1.28 before treatment to 1.9 ± 0.3; VAS score at the left knee joint was decreased from 6.43±1.19 to 2.25±0.43. Total Lequene score at right knee joint was decreased from 16.04±1.57 before treatment to 4.31±1.04, at left knee joint was decreased from 17.52±1.74 before treatment to 5.15. ±1.48. Total WOMAC score at right knee joint was decreased from 55.93±5.56 to 10.37±1.56; at left knee joint was decreased from 53.97±5.57 to 10.07±1.59. There were 86.77% joints with cartilage thickness change and the patellar cartilage thickness was increased from 1.56 ± 0.09 mm before treatment to 1.65 ± 0.09 mm. Combining platelet-rich plasma therapy with mesenchymal stem cells derived from the patient's own adipose tissue to treat knee osteoarthritis is beneficial in lowering pain, enhancing patient mobility and walking ability, and changing the thickness of the articular cartilage on magnetic resonance imaging.