The Role of KLF4 in Alzheimer’s Disease

Cheng, Ziqian and Zou, Xiaohan and Jin, Yang and Gao, Shuohui and Lv, Jiayin and Li, Bingjin and Cui, Ranji (2018) The Role of KLF4 in Alzheimer’s Disease. Frontiers in Cellular Neuroscience, 12. ISSN 1662-5102

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Official URL: https://doi.org/10.3389/fncel.2018.00325

Abstract

Krüppel-like factor 4 (KLF4), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions. Emerging evidence suggest KLF4’s critical regulatory effect on the neurophysiological and neuropathological processes of Alzheimer’s disease (AD), indicating that KLF4 might be a potential therapeutic target of neurodegenerative diseases. In this review, we will summarize relevant studies and illuminate the regulatory role of KLF4 in the neuroinflammation, neuronal apoptosis, axon regeneration and iron accumulation to clarify KLF4’s status in the pathogenesis of AD.

Item Type:	Article
Subjects:	STM Library > Medical Science
Depositing User:	Managing Editor
Date Deposited:	31 May 2023 05:02
Last Modified:	12 Dec 2023 04:09
URI:	http://open.journal4submit.com/id/eprint/2169

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