Assessment of Human Fibrinogen Antigen and Tissue Plasminogen Activator as Hypercoagulability Markers in Type 2 Diabetic Patients in Obio/ Akpor Local Government Area, Rivers State, Nigeria

This is a case controlled study carried out on type 2 Diabetic Patients in Obio/ Akpor Local Government, Rivers State with the aim of determining the haemostatic status. The haemostatic markers were assessed and compared with apparently healthy control subjects without diabetes. A total of 66 Type 2 diabetic patients (36 females and 30 males) aged between 24 and 77 years; 54 subjects (31 females and 23 males) that were apparently healthy of age between 24 and 76years, enrolled as control, with all participants recruited between November 2019 and January 2020. Human fibrinogen antigen and tissue plasminogen activator were analysed with reagents obtained from Elabscience, Wuhan, China and the test carried out with an ELISA machine (STAT FAX-2100).Results showed a significant increase (p<0.05) respectively in mean tissue plasminogen activator and mean human fibrinogen antigen when compared with control. Also there were strong significant correlations (p<0.05) respectively between human fibrinogen antigen and blood glucose, tissue plasminogen activator and blood glucose.There was no significant differences (p<0.05) observed in tissues plasminogen activator and human fibrinogen antigen between Type 2 Diabetic male and female patients. These two haemastatic markers can be used as a predictor indices for management of hypercoagulability in type 2 diabetic patients.