Sickle Cell Anemia Contributes to Liver Abnormality

Aim: This study sought to investigate the implication of sickle cell anemia on hepatic biomarkers.

Methodology: This is a case-control study which enrolled 60 sickle cell anemia patients (30 males and 30 females) in a stable state at the Obafemi Awolowo University Teaching Hospital in Ile-Ife, Osun State, Nigeria, as well as 60 healthy controls (30 males and 30 females). Each participant had five millilitres (5 mL) of venous blood taken and dispensed into a lithium heparin sample vial. Hepatic biomarkers were assessed using established procedures utilizing the blood sample.

Results: Hepatic indices were higher in sickle cell anemia patients than in control subjects, according to the findings of this study. It's worth noting that the effect of sickle cell anemia on liver parameters was stronger in male patients than in females. The activity of ALP in male sickle was 280 UI/L compared to the 198 UI/L in their female counterparts. Both values were significantly (p<0.05) higher than those found in the control subjects. This was not different in other hepatic parameters investigated in this study.

Conclusion: The findings of this investigation revealed that sickle cell patients had significantly higher liver indices than control persons. This could indicate that its synthesis in the liver has been increased or metabolism was reduced sequel to sickle cell disease.