Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2H)-one)[(Pyridin-2-yl)ethylidene]hydrazone

Yong, Joseph N. and Majoumo-Mbe, Felicite and Samje, Moses and Nfor, Emmanuel N. (2016) Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2H)-one)[(Pyridin-2-yl)ethylidene]hydrazone. International Journal of Organic Chemistry, 06 (01). pp. 77-84. ISSN 2161-4687

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Official URL: https://doi.org/10.4236/ijoc.2016.61008

Abstract

The novel ligand, 1-(phthalazin-1(2H)-one)[(pyridin-2-yl)ethylidene]hydrazone,(APN), derived from the antihypertensive drug, hydralazine hydrochloride, was synthesized and characterized by spectroscopic methods (IR, 1H NMR). The X-ray crystallographic data indicates that APN has an exocyclic C=N bond on the hydralazine moiety. APN revealed significant anti-onchocercal activity with IC50 values of 0.3125 μg/mL on microfilaria and 10 μg/mL on adult worms compared to the standard drug, ivermectin.

Item Type:	Article
Subjects:	STM Library > Chemical Science
Depositing User:	Managing Editor
Date Deposited:	09 Feb 2023 07:02
Last Modified:	17 Jun 2024 06:00
URI:	http://open.journal4submit.com/id/eprint/1015

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