Applications of a Single Molecule Theory of Protein Dynamics

Yi, Fang (2024) Applications of a Single Molecule Theory of Protein Dynamics. Journal of Biosciences and Medicines, 12 (06). pp. 311-335. ISSN 2327-5081

[thumbnail of jbm_2024070312553434.pdf] Text
jbm_2024070312553434.pdf - Published Version

Download (498kB)


A single molecule theory for protein dynamics has been developed since 2012. It consists of the concepts of conformational Gibbs free energy function (CGF) and single molecule thermodynamic hypothesis (STH) that claims that all stable conformations are (local or global) minimizers of CGF. These are enough to give a unified explanations and mechanisms to many aspects of protein dynamics such as protein folding; allostery; denaturation; and intrinsically disordered proteins. Formulas of CGF in water environment had been derived via quantum statistics. Applications of them to soluble proteins are: docking Gibbs free energy difference formula and a practical way to search better docking site; single molecule binding affinity; predicting and explaining why structures of a monomeric globular protein looks like a globule and is tightly packed with a hydrophobic core; a representation of the hydrophobic effect; and a wholistic view to structures of water soluble proteins.

Item Type: Article
Subjects: STM Library > Medical Science
Depositing User: Managing Editor
Date Deposited: 06 Jul 2024 10:52
Last Modified: 06 Jul 2024 10:52

Actions (login required)

View Item
View Item