Platelet Microparticle Controversial Role in Cancer

Nazari, Mahnaz and Javandoost, Ehsan and Talebi, Mehdi and Movassaghpour, Aliakbar and Soleimani, Masoud (2020) Platelet Microparticle Controversial Role in Cancer. Advanced Pharmaceutical Bulletin, 11 (1). pp. 39-55. ISSN 2228-5881

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Platelet-derived microparticles (PMPs) are a group of micrometer-scale extracellular vesicles released by platelets upon activation that are responsible for the majority of microvesicles found in plasma. PMPs’ physiological properties and functions have long been investigated by researchers. In this regard, a noticeable area of studies has been devoted to evaluating the potential roles and effects of PMPs on cancer progression. Clinical and experimental evidence conflictingly implicates supportive and suppressive functions for PMPs regarding cancer. Many of these functions could be deemed as a cornerstone for future considerations of PMPs usage in cancer targeted therapy. This review discusses what is currently known about PMPs and provides insights for new and possible research directions for further grasping the intricate interplay between PMPs and cancer.

Item Type: Article
Subjects: STM Library > Multidisciplinary
Depositing User: Managing Editor
Date Deposited: 01 Apr 2023 05:26
Last Modified: 13 Jan 2024 04:15

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